首页> 外国专利> Methods of treating or preventing and controlling a myeloproliferative disease, reducing or preventing an adverse effect associated with the administration of a second active agent in a patient suffering from a myeloproliferative disease and enhancing the therapeutic efficacy of a myeloproliferative disease treatment, composition. pharmaceutical and kit

Methods of treating or preventing and controlling a myeloproliferative disease, reducing or preventing an adverse effect associated with the administration of a second active agent in a patient suffering from a myeloproliferative disease and enhancing the therapeutic efficacy of a myeloproliferative disease treatment, composition. pharmaceutical and kit

机译：在患有骨髓增生性疾病的患者中治疗或预防和控制骨髓增生性疾病，减少或预防与施用第二种活性剂相关的不良作用以及增强骨髓增生性疾病治疗组合物的治疗功效的方法。药品和试剂盒

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摘要

"METHODS OF TREATING OR PREVENTING AND CONTROLING A MYELOPROLIFERATIVE DISEASE, REDUCING OR AVOIDING AN ADVERSE EFFECT ASSOCIATED WITH ADMINISTRATION OF A SECOND ACTIVE PATIENT WITH A THERAPELE DEVELOPMENTAL MYELOPROATIA DISEASE PHARMACEUTICAL COMPOSITION AND KIT ". Methods of treating, preventing and / or controlling a myeloproliferative disease are described. Specific methods include administering an immunomodulatory compound, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active agent, and / or transplantation. of blood or cells. Second specific active agents are capable of suppressing hematopoietic stem cell overproduction or amelioration of one or more of the symptoms of a myeloproliferative disease. Pharmaceutical compositions, unit dosage forms, and kits suitable for using the methods of the invention are also described.

机译：“治疗或预防和控制骨髓增生性疾病，减少或避免伴随第二积极患者的治疗而发生的不良反应的方法，所述患者与治疗性发展性骨髓炎的疾病药物组合物和试剂盒有关。”描述了治疗，预防和/或控制骨髓增生性疾病的方法。具体方法包括单独或与第二活性剂组合施用免疫调节化合物或其药学上可接受的盐，溶剂化物，水合物，立体异构体，包合物或前药和/或移植。血液或细胞。第二种特异性活性剂能够抑制造血干细胞过度生产或减轻骨髓增生性疾病的一种或多种症状。还描述了适用于使用本发明方法的药物组合物，单位剂型和试剂盒。

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公开/公告号BR0316082A

专利类型
公开/公告日2005-09-27

原文格式PDF
申请/专利权人 CELGENE CORPORATION;
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申请/专利号BR20030316082
发明设计人 JEROME B. ZELDIS;
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申请日2003-04-13
分类号A61K31/445;A61K39/395;A61K48/00;C07D401/04;
国家 BR
入库时间 2022-08-21 22:18:32

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