首页> 外国专利> Process for the production of 6, 7- dihydroxy steroid compounds by allylic oxidation of steroid - 5 - ene compounds to steroid - 5 - ene - 7 - one compounds followed by hydroboration and oxidation and intermediates of this process

Process for the production of 6, 7- dihydroxy steroid compounds by allylic oxidation of steroid - 5 - ene compounds to steroid - 5 - ene - 7 - one compounds followed by hydroboration and oxidation and intermediates of this process

机译：通过类固醇-5-烯化合物的烯丙基氧化为类固醇-5-烯-7-一种化合物，然后进行硼氢化和氧化反应以及该方法的中间体来生产6，7-二羟基甾类化合物的方法

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摘要

Steroids containing a cyclohexene moiety are efficiently oxidized to the corresponding , -unsaturated ketone using copper iodide and t-butyl hydroperoxide. A steroid compound containing the , -unsaturated ketone structure is efficiently converted to the corresponding vicinal diol using a hydroborating reagent followed by oxidative workup, e.g., borane followed by sodium perborate. Benzoyl and substituted benzoyls are superior protecting groups for hydroxyl groups present in the compounds.

机译：使用碘化铜和叔丁基氢过氧化物将含有环己烯部分的类固醇有效地氧化为相应的不饱和酮。使用氢硼化试剂，然后进行氧化处理，例如硼烷，然后过硼酸钠，将含有不饱和酮结构的甾族化合物有效地转化为相应的邻位二醇。苯甲酰基和取代的苯甲酰基是化合物中存在的羟基的优异保护基。

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公开/公告号US2004266744A1

专利类型
公开/公告日2004-12-30

原文格式PDF
申请/专利权人 BURGOYNE DAVID L;SHEN YAPING;JI GUEIJUN;ZHOU YUANLIN;RAMACHANDRAN KISHORE D;PASCHALIDES NICHOLAS D;KELLEHER EUGENE W;
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申请/专利号US20040478581
发明设计人 DAVID L BURGOYNE;YAPING SHEN;GUEIJUN JI;YUANLIN ZHOU;KISHORE D. RAMACHANDRAN;NICHOLAS D. PASCHALIDES;EUGENE W. KELLEHER;
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申请日2004-07-15
分类号A61K31/56;C07J53/00;
国家 US
入库时间 2022-08-21 22:20:49

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