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Compositions and kits for differential diagnosis of hydatidiform moles and methods of using the same

机译:鉴别葡萄胎的组合物和试剂盒及其使用方法

摘要

The present invention provides various antibody and nucleic acid compositions useful in the differential diagnosis of hydatidiform mole. In particular, the invention discloses compositions comprising antibodies specifically targeted to bind to amino acid residues 102-120 or 134-152 of the human IPL protein, as well as compositions comprising nucleic acids that specifically hybridize to target nucleic acids encoding amino acid residues 102-120 or 134-152 of the human IPL protein. The invention further discloses methods of using the subject antibody and nucleic acid compositions to differentially diagnose complete hydatidiform mole in a subject. Also provided are kits for diagnosing complete hydatidiform mole, where the kits comprise the antibodies or nucleic acids of the present invention.
机译:本发明提供了用于鉴别葡萄胎的各种抗体和核酸组合物。特别地,本发明公开了包含特异性靶向结合人IPL蛋白的氨基酸残基102-120或134-152的抗体的组合物,以及包含与编码氨基酸残基102-102的靶核酸特异性杂交的核酸的组合物人类IPL蛋白的120或134-152。本发明进一步公开了使用本发明的抗体和核酸组合物来鉴别诊断对象中完整的葡萄胎的方法。还提供了用于诊断完整的葡萄胎的试剂盒,其中所述试剂盒包含本发明的抗体或核酸。

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