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Genes encoding single chain human leukocyte antigen E (HLA-E) proteins to prevent natural killer cell-mediated cytotoxicity and cytotoxic T Lymphocyte (CTL)-mediated cytotoxicity
Genes encoding single chain human leukocyte antigen E (HLA-E) proteins to prevent natural killer cell-mediated cytotoxicity and cytotoxic T Lymphocyte (CTL)-mediated cytotoxicity
The present invention describes a gene encoding a single polypeptide encoding three components of HLA-E cell surface expression. When the gene is introducted into porcine cells it fold properly and confers protection against human NK cell-mediated killing. Additionally, this invention provides a method to inhibit CTL-mediated killing of cells.
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