首页> 美国政府科技报告 >Genes Encoding Single Chain Human Leukocyte Antigen E (HLA-E) Proteins to Prevent Natural Killer Cell-Mediated Cytotoxicity and Cytotoxic T Lymphocyte (CTL)-Mediated Cytotoxicity.

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Genes Encoding Single Chain Human Leukocyte Antigen E (HLA-E) Proteins to Prevent Natural Killer Cell-Mediated Cytotoxicity and Cytotoxic T Lymphocyte (CTL)-Mediated Cytotoxicity.

机译：编码单链人白细胞抗原E（HLa-E）蛋白的基因，以防止自然杀伤细胞介导的细胞毒性和细胞毒性T淋巴细胞（CTL）介导的细胞毒性。

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摘要

The present invention describes a gene encoding a single polypeptide encoding three components of HLA-E cell surface expression. When the gene is introducted into porcine cells it fold properly and confers protection against human NK cell-mediated killing. Additionally, this invention provides a method to inhibit CTL-mediated killing of cells.

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作者
Crew, M. D.;
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年度 2005
页码 1-28
总页数 28
原文格式 PDF
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关键词
Genes; Leukocytes; Antigens; Cytotoxicity; Patent applications; Cell cultures; Proteins; Gene expression; Peptides; Disease prevention; Inhibitors;

机译：基因;白细胞;抗原;细胞毒性;专利申请;细胞培养;蛋白质;基因表达;肽;疾病预防;抑制剂;

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专利

1. Transgenic expression of HLA-E single chain trimer protects porcine endothelial cells against human natural killer cell-mediated cytotoxicity. [J] . Lilienfeld BG, Crew MD, Forte P, Xenotransplantation . 2007,第2期

机译：HLA-E单链三聚体的转基因表达可保护猪内皮细胞免受人类自然杀伤细胞介导的细胞毒性作用。
2. Human fibroblasts transfected with cytomegalovirus immediate-early genes show increased MHC class I expression and are targets for natural killer cell-mediated cytotoxicity. [J] . Nyquist AC, Zhang L, Weinberg A Viral immunology . 2002,第1期

机译：用巨细胞病毒立即早期基因转染的人类成纤维细胞显示出MHC I类表达增加，并且是自然杀伤细胞介导的细胞毒性的靶标。
3. Requirement of expression of P-glycoprotein on human natural killer leukemia cells for cell-mediated cytotoxicity. [J] . Yamashiro T, Watanabe N, Yokoyama KK, Biochemical Pharmacology . 1998,第9期

机译：P-糖蛋白在人自然杀伤性白血病细胞上表达对细胞介导的细胞毒性的要求。
4. Unsupervised selection of RV144 HIV vaccine-induced antibody features correlated to natural killer cell-mediated cytotoxic reactions [C] . Ferdi Sarac, Volkan Uslan, Huseyin Seker, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2016

机译：RV144 HIV疫苗诱导的抗体特征的无监督选择与自然杀伤细胞介导的细胞毒性反应有关
5. LAMININ: A POSSIBLE ROLE AS A MEDIATOR OF NATURAL CELL-MEDIATED FUNCTIONS (NATURAL KILLER CELLS, NATURAL CYTOTOXIC CELLS, RECEPTORS, SURFACE ANTIGEN). [D] . LAYBOURN, KATHERINE ANN. 1986

机译：层粘连蛋白：作为天然细胞介导的功能（天然杀伤细胞，天然细胞毒性细胞，受体，表面抗原）的介体的可能作用。
6. A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity. [O] . B Lowin, F Beermann, A Schmidt, 1994

机译：穿孔素基因的无效突变会损害溶细胞性T淋巴细胞和自然杀伤细胞介导的细胞毒性。
7. A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity. [O] . Lowin, B, Beermann, F, Schmidt, A, 1994

机译：穿孔素基因的无效突变会损害溶细胞性T淋巴细胞和自然杀伤细胞介导的细胞毒性。
8. Studies of Cell-Mediated Immunity to Measles Virus by in Vitro Lymphocyte-Mediated Cytotoxicity. [R] . Labowskie, R. J., Edelman, R., Rustigian, R., 1972

机译：通过体外淋巴细胞介导的细胞毒性研究细胞介导的麻疹病毒免疫。

Genes Encoding Single Chain Human Leukocyte Antigen E (HLA-E) Proteins to Prevent Natural Killer Cell-Mediated Cytotoxicity and Cytotoxic T Lymphocyte (CTL)-Mediated Cytotoxicity.

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