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Treatment of chronic myeloid leukemia resistant or intolerant to STI571 using homoharringtonine alone or in combination with other drugs

机译:单独或与其他药物联合使用高灵顿碱治疗对STI571耐药或不耐受的慢性粒细胞白血病

摘要

The present invention concerns a method of treating chronic myelogenous leukemia, a related myeloproliferative disorder or a Ph-positive acute lymphocytic leukemia in a subject animal, comprising: (a) selecting or identifying an animal suffering from chronic myelogenous leukemia or a related myeloproliferative disorder and showing resistance or intolerance to treatment with STI571; and (b) administering to the animal homoharringtonine. In a preferred embodiment, the animal is a human being.
机译:本发明涉及一种在对象动物中治疗慢性粒细胞性白血病,相关的骨髓增生性疾病或Ph阳性急性淋巴细胞性白血病的方法,包括:(a)选择或鉴定患有慢性粒细胞性白血病或相关的骨髓增生性疾病并且对STI571治疗表现出抗性或不耐受性的动物;和(b)对动物施用高灵顿碱。在一个优选的实施方案中,动物是人。

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