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Amphiphilic biodegradable block copolymers comprising polyethylenimine(PEI) as a hydrophilic block and polyester as a hydrophobic block, and self-assembled polymer aggregates in aqueous milieu formed from the block copolymers
Amphiphilic biodegradable block copolymers comprising polyethylenimine(PEI) as a hydrophilic block and polyester as a hydrophobic block, and self-assembled polymer aggregates in aqueous milieu formed from the block copolymers
There are provided amphiphilic biodegradable block copolymers comprising polyethylenimine (PEI) as a hydrophilic block and aliphatic polyesters as a hydrophobic block, which can form various size of polymer aggregates and have very low critical micelle concentration, approximately 10-3g/ l in comparison with low-molecular-weight micelle, and self-assembled polymer aggregates formed from the block copolymers in aqueous milieu, which can be applied to solubilization of insoluble drug and a delivery system of proteins, genes or drugs.
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机译：提供了两亲性可生物降解的嵌段共聚物，其包含聚乙烯亚胺（PEI）作为亲水性嵌段和脂族聚酯作为疏水性嵌段，其可以形成各种尺寸的聚合物聚集体并且具有非常低的临界胶束浓度，约10 -3 g / l。与低分子量胶束的比较，以及由嵌段共聚物在水性环境中形成的自组装聚合物聚集体，可用于增溶不溶性药物和蛋白质，基因或药物的递送系统。
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