首页> 外国专利> NOVEL METHOD FOR SCREENING INHIBITORS OF THE LINKAGE BETWEEN THE NEURONAL NITRIC OXIDE SYNTHASE ASSOCIATED PROTEIN AND THE PROTEIN INHIBITING NEURONAL NITRIC OXIDE SYNTHASE

NOVEL METHOD FOR SCREENING INHIBITORS OF THE LINKAGE BETWEEN THE NEURONAL NITRIC OXIDE SYNTHASE ASSOCIATED PROTEIN AND THE PROTEIN INHIBITING NEURONAL NITRIC OXIDE SYNTHASE

机译:筛选抑制神经一氧化氮合酶的蛋白质和抑制神经一氧化氮合酶的蛋白质连锁的抑制剂的新方法。

摘要

The invention concerns a detection procedure for compounds modulating the complexation between neuronal nitric oxide synthase protein (nNOS) or one of its variants and the protein inhibitor of neuronal nitric oxide synthase (PIN), in which: a mixture of the said compound, the PIN and the nNOS or one of its variants is incubated, significant variation in the quantity of complex formed between the PIN and the nNOS or one of its variants with respect to a control value is detected, when there is significant variation as defined above, it is concluded that there is binding between the said compound and the PIN, or between the said compound and the nNOS or one of its variants, leading to modulation of the complexation between the PIN and nNOS or one of its variants.
机译:本发明涉及用于调节神经元一氧化氮合酶蛋白(nNOS)或其变体之一与神经元一氧化氮合酶(PIN)的蛋白抑制剂之间的复合的化合物的检测方法,其中:所述化合物,PIN的混合物孵育nNOS或其变体之一后,检测到PIN和nNOS或其变体之一之间形成的复合物数量相对于对照值的显着变化,当存在如上定义的显着变化时,得出的结论是,所述化合物与PIN之间或所述化合物与nNOS或其变体之一之间存在结合,从而导致PIN与nNOS或其变体之一之间的复合作用得到调节。

著录项

  • 公开/公告号EP1379876A2

    专利类型

  • 公开/公告日2004-01-14

    原文格式PDF

  • 申请/专利权人 INNODIA;

    申请/专利号EP20020726262

  • 申请日2002-04-17

  • 分类号G01N33/573;C07K7/06;C12Q1/26;C12N9/02;

  • 国家 EP

  • 入库时间 2022-08-21 22:53:53

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