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NOVEL METHOD FOR SCREENING INHIBITORS OF THE LINKAGE BETWEEN THE NEURONAL NITRIC OXIDE SYNTHASE ASSOCIATED PROTEIN AND THE PROTEIN INHIBITING NEURONAL NITRIC OXIDE SYNTHASE
NOVEL METHOD FOR SCREENING INHIBITORS OF THE LINKAGE BETWEEN THE NEURONAL NITRIC OXIDE SYNTHASE ASSOCIATED PROTEIN AND THE PROTEIN INHIBITING NEURONAL NITRIC OXIDE SYNTHASE
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机译:筛选抑制神经一氧化氮合酶的蛋白质和抑制神经一氧化氮合酶的蛋白质连锁的抑制剂的新方法。
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DESCRIPTIVE SUMMARY NEW SCREENING PROCEDURE FOR INHIBITORS OF THE BONDBETWEEN NEURONAL NITRIC OXIDE SYNTHASE AND THE PROTEININHIBITOR OF NEURONAL NITRIC OXIDE SYNTHASEThe invention concerns a detection procedure for compounds modulating the complexation between neuronal nitric oxide synthase protein (nNOS) or one of its variants and the protein inhibitor of neuronal nitric oxide synthase (PIN), in which:- a mixture of the said compound, the PIN and the nNOS or one of its variants is incubated,- significant variation in the quantity of complex formed between the PIN and the nNOS or one of its variants with respect to a control value is detected,- when there is significant variation as defined above, it is concluded that there is binding between the said compound and the PIN, or between the said compound and thenNOS or one of its variants, leading to modulation of the complexation between the PIN and nNOS or one of its variants.(no figures)
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