首页> 外国专利> NOVEL METHOD FOR SCREENING INHIBITORS OF THE LINKAGE BETWEEN THE NEURONAL NITRIC OXIDE SYNTHASE ASSOCIATED PROTEIN AND THE PROTEIN INHIBITING NEURONAL NITRIC OXIDE SYNTHASE

NOVEL METHOD FOR SCREENING INHIBITORS OF THE LINKAGE BETWEEN THE NEURONAL NITRIC OXIDE SYNTHASE ASSOCIATED PROTEIN AND THE PROTEIN INHIBITING NEURONAL NITRIC OXIDE SYNTHASE

机译:筛选抑制神经一氧化氮合酶的蛋白质和抑制神经一氧化氮合酶的蛋白质连锁的抑制剂的新方法。

摘要

DESCRIPTIVE SUMMARY NEW SCREENING PROCEDURE FOR INHIBITORS OF THE BONDBETWEEN NEURONAL NITRIC OXIDE SYNTHASE AND THE PROTEININHIBITOR OF NEURONAL NITRIC OXIDE SYNTHASEThe invention concerns a detection procedure for compounds modulating the complexation between neuronal nitric oxide synthase protein (nNOS) or one of its variants and the protein inhibitor of neuronal nitric oxide synthase (PIN), in which:- a mixture of the said compound, the PIN and the nNOS or one of its variants is incubated,- significant variation in the quantity of complex formed between the PIN and the nNOS or one of its variants with respect to a control value is detected,- when there is significant variation as defined above, it is concluded that there is binding between the said compound and the PIN, or between the said compound and thenNOS or one of its variants, leading to modulation of the complexation between the PIN and nNOS or one of its variants.(no figures)
机译:描述性摘要 债券担保人的新审查程序神经一氧化氮合酶与蛋白质之间神经一氧化氮合酶的抑制剂本发明涉及一种检测化合物的调控方法一氧化氮合酶蛋白(nNOS)或其一种之间的复合神经元一氧化氮合酶(PIN)的变体和蛋白抑制剂,其中:-所述化合物,PIN和nNOS或其变体之一的混合物是孵化-PIN和PIN之间形成的络合物数量有很大变化检测到nNOS或其相对于控制值的一种变化,-当存在以上定义的显着变化时,得出结论是存在所述化合物与PIN之间或所述化合物与nNOS或其变体之一,导致PIN之间的复杂度得到调节和nNOS或其变体之一。(无数字)

著录项

  • 公开/公告号SG100875A1

    专利类型

  • 公开/公告日2004-01-30

    原文格式PDF

  • 申请/专利权人 INNODIA;

    申请/专利号SG2003062247

  • 申请日2002-04-17

  • 分类号G01N33/573;C07K7/06;C12Q1/26;C12N9/02;

  • 国家 SG

  • 入库时间 2022-08-21 23:08:01

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