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REGULATION OF TRANSCRIPTION ELONGATION FACTORS

机译:转录延伸因子的调节

摘要

The present invention relates to agents, including siRNA and shRNA molecules, small molecules, antisense strands, and ribozymes that are targeted to transcription elongation factors (TEFs), including CDK9 and CycTI, subunits of P-TEFb, Spt4 and Spt5, subunits of DSIF (DRB Sensitivity-Inducing Factor (DSIF)), and Spt6. The present invention also relates to methods for treating disorders associated with aberrant or unwanted TEF expression or activity, including HIV and disorders characterized by unwanted or aberrant cellular proliferation or differentiation, such as cancer.
机译:本发明涉及试剂,包括靶向转录延长因子(TEF)的siRNA和shRNA分子,小分子,反义链和核酶,包括CDK9和CycTI,P-TEFb,Spt4和Spt5的亚基,DSIF的亚基(DRB敏感性诱导因子(DSIF))和Spt6。本发明还涉及用于治疗与异常或不希望的TEF表达或活性有关的疾病,包括HIV和以不希望或异常的细胞增殖或分化为特征的疾病,例如癌症的方法。

著录项

  • 公开/公告号AU2003261405A1

    专利类型

  • 公开/公告日2004-06-07

    原文格式PDF

  • 申请/专利权人 UNIVERSITY OF MASSACHUSETTS;

    申请/专利号AU20030261405

  • 发明设计人 TARIQ M. RANA;YA-LIN CHIU;

    申请日2003-08-05

  • 分类号C07H21/02;A61K48/00;C12N15/85;C12N15/86;C12Q1/68;

  • 国家 AU

  • 入库时间 2022-08-21 23:02:43

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