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首页> 外国专利> Agent to monitor the activity of angiotensin I converting enzyme (ACE) the basis of synthetic substrates fluorescence erased; the method of monitoring of ace for the diagnosis of diseases GRanulomatosas; method of determining the enzymatic activity of ace in plasma or serum.Use of fluorescent substrates in dosage of ACE erased fluids and biological tissues and kit for diagnosis.

Agent to monitor the activity of angiotensin I converting enzyme (ACE) the basis of synthetic substrates fluorescence erased; the method of monitoring of ace for the diagnosis of diseases GRanulomatosas; method of determining the enzymatic activity of ace in plasma or serum.Use of fluorescent substrates in dosage of ACE erased fluids and biological tissues and kit for diagnosis.

机译：监测血管紧张素I转化酶（ACE）活性的试剂，在合成底物上消除了荧光;用ace监测疾病诊断肉芽肿的方法;测定血浆或血清中ace的酶活性的方法。荧光底物在ACE擦除液和生物组织的剂量中的使用以及诊断试剂盒。

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"Agent to monitor the activity of converting enzyme (ACE) angiotensiua I based on synthetic substrates fluorescence erased; the method of monitoring of ace for the diagnosis of diseasesGranulomatous; method of determining the enzymatic activity of ace in plasma or serum.Use of fluorescent substrates in dosage of ACE erased fluids and biological tissues and kit for diagnosis.The invention relates to an agent monitor the activity of angiotensin I converting enzyme (ACE) the basis of substrate fluorescence wiped out.The method of monitoring the enzymatic activity of ace for the diagnosis of granulomatous diseases.The method of determining the enzymatic activity of ace in plasma or serum and the use of substrates of fluorescence erased during the determination of ace in biological fluids and tissues and also the kit for diagnu00f3stico containing said agent.Specifically, the substrates are peptides of type ABZ peptidil - K (DNP) P - Oh, in which the fluorescent probe is connected on the end ABZ n - terminal group and the fluorescence quencher DNP (2)4 dinitrofenil) coupled on the sym - amino group of a lysine and proline residue placed in the position C - terminal giving the peptide hydrolysis resistance by carboxipeptidases favouring inTerau00e7u00e3o enzyme - substrate the method of monitoring the enzymatic activity of ACE using substrates with erasure intramolecular fluorescence is useful in the diagnosis of diseases in serum and plasma.Human. The agent monitor presents practical applicability in laboratories that dose ace at clinical level.
机译：“基于合成底物的荧光擦除来监测转化酶（ACE）血管紧张素I的活性的试剂;用于诊断肉芽肿的ace的监测方法;确定血浆或血清中ace的酶活性的方法。使用荧光ACE擦除的液体和生物组织中的底物以及用于诊断的试剂盒。本发明涉及一种监测剂，其作用是清除掉底物荧光的基础上的血管紧张素I转化酶（ACE）活性。监测ace的酶活性的方法测定血浆或血清中ace的酶活性的方法以及在测定生物体液和组织中ace的过程中使用擦除的荧光底物的方法以及含有该试剂的诊断试剂盒。 ，底物是ABZ肽-K（DNP）P-OH型的肽，其中荧光探针连接在末端ABZ n-末端基团和荧光淬灭剂DNP（2）4二硝基苯胺）偶联在赖氨酸的脯氨酸和脯氨酸残基的C-末端上，从而使羧肽酶对肽具有抗水解性，有利于Tera u00e7 u00e3o酶-底物使用具有擦除分子内荧光的底物来监测ACE酶活性的方法可用于诊断血清和血浆中的疾病。药剂监测器可在实验室中以临床水平对ace进行剂量测定，从而提供实际的适用性。

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