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Decision manner null of the liver cell cancer which uses the marker and the said marker for liver cell cancer decision

机译:使用标记物和所述标记物进行肝细胞癌判定的肝细胞癌判定方式无效

摘要

PURPOSE: To judge the danger of the advance and of the outbreak of hepatoma by using a marker, for judgement of hepatoma, which uses a seventh GIa incomplete blood coagulation factor (PIVKA-VII) as essence. ;CONSTITUTION: A monoclonal antibody which does not react with a seventh blood coagulation factor but which has a reactivity only to a PIVKA-VII is prepared, it is used as a solid-phase antibody or a marker antibody in an enzyme immunoassay method or a radioimmunoassary method based of a double antibody sandwich assay method, and the PIVKA-VII in a biological sample is detected directly. The existence of the PIVKA-VII indicates a positive rate of 100% at patients who are positive to α1 fetoprotein (AFP) and who are positive to the PIVKA-VII, and it displays a positive rate of 100% even at patients who are negative to the AFP but who are positive to the PIVKA-VII. In addition, since 83% of patients who are negative to both AFP and PIVKA-VII markers, are positive, a hepatoma patient can be screened at an extremely high probability.;COPYRIGHT: (C)1996,JPO
机译:目的:通过使用标记物来判断肝癌进展和爆发的危险,并以第七种GIa不完全凝血因子(PIVKA-VII)为本质来判断肝癌。 ;组成:不与第七凝血因子反应但仅对PIVKA-VII具有反应性的单克隆抗体,在酶免疫测定法或免疫印迹法中用作固相抗体或标志物抗体。基于双抗体夹心测定法的放射免疫法,直接检测生物样品中的PIVKA-VII。 PIVKA-VII的存在表明α 1 胎儿蛋白(AFP)阳性且PIVKA-VII阳性的患者的阳性率为100%,并且它显示阳性率即使对AFP阴性但对PIVKA-VII阳性的患者,也只有100%的患者。此外,由于83%的AFP和PIVKA-VII标记均为阴性的患者呈阳性,因此可以极高的可能性筛查肝癌患者。版权所有:(C)1996,JPO

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