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FATTY ACID CONJUGATION AS A METHOD FOR SCREENING OF POTENTIALLY BIOACTIVE SUBSTANCES

机译:脂肪酸共轭作为潜在生物活性物质的筛选方法

摘要

The present invention relates to a method for screening of compounds or molecules that undergo conjugation with fatty acids present in a mammal body, including humans, whereby a compound to be tested is brought into contact with a fatty acid together with a tissue homogenate or an enzyme, whereupon any conjugation between the compound and any fatty acid present in said homogenate is determined with regard to presence of fatty acid amides, esters or thioesters, as well as a kit for conjugation of such compounds or molecules with fatty acids.
机译:本发明涉及一种用于筛选与包括人在内的哺乳动物体内存在的脂肪酸共轭的化合物或分子的方法,从而使待测化合物与脂肪酸以及组织匀浆或酶接触。 ,然后根据脂肪酸酰胺,酯或硫代酯的存在确定化合物与所述匀浆中存在的任何脂肪酸之间的任何缀合,以及用于将此类化合物或分子与脂肪酸缀合的试剂盒。

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