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A CRYSTALLISED CATALYTIC DOMAIN OF MATRIX METALLOPROTEINASE 9 (MMP9) AND THE USE OF ITS THREE DIMENSIONAL STRUCTURE TO DESIGN MMP9 MODULATORS
A CRYSTALLISED CATALYTIC DOMAIN OF MATRIX METALLOPROTEINASE 9 (MMP9) AND THE USE OF ITS THREE DIMENSIONAL STRUCTURE TO DESIGN MMP9 MODULATORS
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机译:基质金属蛋白酶9(MMP9)的结晶催化域及其在三维结构设计MMP9调制器中的使用
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摘要
The invention provides a crystalline form of a polypeptide corresponding to the catalytic domain of a matrix metalloproteinase protein, MMP9. The active site binding region of the MMP9 protein is defined by its amino acid residues and their atomic coordinates. This three dimensional structure may be used to select or design chemical modulators of MMP9, particularly MMP9 inhibitors. These modulators may be used to treat a metalloproteinase mediated disease or condition.
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