A NOVEL HUMAN LEUCINE-RICH REPEAT CONTAINING PROTEIN EXPRESSED PREDOMINATELY IN SMALL INTESTINE, HLRRSI1

• 1. 含有富含亮氨酸重复序列的融合蛋白及其制法和应用 [P] . 中国专利： CN104119448A . 2014-10-29
• 2. 含有富含亮氨酸重复序列的融合蛋白及其制法和应用 [P] . 中国专利： CN104119446A . 2014-10-29
• 3. Human leucine-rich repeat containing protein expressed predominately in small intestine, HLRRSI1 [P] . 美国专利： US7183379B2 . 2007-02-27

  机译： 富含人亮氨酸重复序列的蛋白质主要在小肠HLRRSI1中表达

• 4. Human leucine-rich repeat containing protein expressed predominately in small intestine, HLRRSI1 [P] . 美国专利： US6858407B2 . 2005-02-22

  机译： 富含人亮氨酸重复序列的蛋白质主要在小肠HLRRSI1中表达

• 5. HUMAN LEUCINE-RICH REPEAT CONTAINING PROTEIN EXPRESSED PREDOMINATELY IN SMALL INTESTINE, HLRRSI1 [P] . 世界知识产权组织专利： WO02061086A3 . 2004-02-19

  机译： HLRRSI1在小肠中优先表达富含人亮氨酸的重复蛋白。

• 1. Expression and sub-cellular localization of leucine-rich repeats and immunoglobulin-like domains are related to antioxidant enzymes in human ependymoma and oligodendroglioma [J] . Wei Yi, Lin Liu, Okechi Humphrey, 中国神经再生研究（英文版） . 2011,第011期
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• 1. Leucine-rich repeat-containing G protein-coupled receptor 5 marks different cancer stem cell compartments in human Caco-2 and LoVo colon cancer lines [J] . Samah Abdulaali Alharbi ,Dmitry A Ovchinnikov ,Ernst Wolvetang . 世界胃肠病学杂志：英文版 . 2021,第15期
• 2. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004） （P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期
• 3. Down-regulation of Leucine-rich Repeats and Immunoglobulin-like Domain Proteins (LRIG1-3) in HP75 Pituitary Adenoma Cell Line [J] . GUO Dongsheng ,HAN Lin ,SHU Kai . 华中科技大学学报（医学）（英德文版） . 2007,第001期
• 4. 富含半胱氨酸的酸性分泌蛋白在人骨肉瘤中的表达和意义 [C] . 杨勇昆 ,牛晓辉 . 第八届中国肿瘤学术大会暨第十三届海峡两岸肿瘤学术会议 . 2014
• 5. 富含亮氨酸重复序列的G蛋白偶联受体5(LGR5)的表达与中国人肝癌临床病理相关性研究 [A] . 张剑 . 2017