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A method for generating immunogens that elicit neutralizing antibodies against fusion-active regions of HIV envelope proteins.
A method for generating immunogens that elicit neutralizing antibodies against fusion-active regions of HIV envelope proteins.
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机译:一种产生免疫原的方法,该免疫原引发针对HIV包膜蛋白融合活性区域的中和抗体。
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摘要
The current invention relates to methods of generating immunogens that elicit broadly neutralizing antibodies which target regions of viral envelope proteins such as the gp 120/gp41 complex of HIV-1. More specifically, the current invention involves using stabilizing peptides modeling the alpha-helical regions of the ectodomain of the HIV-1 transmembrane protein to stabilize fusion-active intermediate structures which can be used as vaccine immunogens.
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