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首页> 外文会议>American Peptide Symposium >Synthesis of HIV Gp41 Trimer Mimics Inducing Neutralizing Antibodies Based on Remodeling of Dynamic Structures of HIV-1 Envelope Proteins
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Synthesis of HIV Gp41 Trimer Mimics Inducing Neutralizing Antibodies Based on Remodeling of Dynamic Structures of HIV-1 Envelope Proteins

机译：基于HIV-1包络蛋白动态结构的重塑诱导中和抗体的HIV GP41三聚体模拟物的合成

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Development of new anti-HIV drugs such as protease inhibitors and integrase inhibitors has contributed to highly active anti-retroviral therapy (HAART) for AIDS. We have also developed several anti-HIV agents including CXCR4 antagonists [1], CD4 mimics [2] and integrase inhinitors [3]. Although practically useful drugs have been discovered, the antibody therapy is still a promising and desirable treatment. To develop effective HIV vaccines, artificial antigen molecules have been synthesized based on HIV-1 envelope proteins such as gp120 and gp41. Gp41 plays a pivotal role in the membrane fusion process of HIV-1 infection, and is divided by the N-terminal helix region (N36) and the C-terminal helix region (C34). In the membrane fusion process, a six-helical bundle structure of gp41 is formed, which consists of a trimeric coiled-coil of N36 surrounded by three strands of C34 in an antiparallel fashion. Thus, it suggests that antibodies, which recognize the N36 trimer and the C34 trimer, might block HIV-1-entry.
机译：新的抗HIV药物如蛋白酶抑制剂和整合酶抑制剂的开发有助于艾滋病的高活性抗逆转录病毒治疗（HAART）。我们还开发了几种抗HIV药剂，包括CXCR4拮抗剂[1]，CD4模拟[2]和整合酶吸入器[3]。虽然已经发现了实际上有用的药物，但抗体治疗仍然是一个有前途和理想的治疗方法。为了开发有效的HIV疫苗，已经基于HIV-1包络蛋白（例如GP120和GP41）合成人工抗原分子。 GP41在HIV-1感染的膜融合过程中起着枢轴作用，并由N-末端螺旋区域（N36）和C末端螺旋区域（C34）除以。在膜融合过程中，形成了GP41的六螺旋束结构，其由N36的三聚体卷曲线圈组成，其由三个C34括在反平行时尚。因此，它表明，识别N36三聚体和C34三聚体的抗体可能阻断HIV-1进入。

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