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Screening method for Pax4 gene expression enhancing substance and pharmaceutical composition for enhancing Pax4 gene expression

机译：Pax4基因表达增强物质的筛选方法及增强Pax4基因表达的药物组合物

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摘要

The screening method of the present invention selects a substance capable of enhancing Pax4 gene expression in pancreatic. Beta. - cells which is useful for protecting pancreatic beta cells from exhaustion or enhancing pancreatic beta cell function. In addition, the substance and / or activin receptor activator obtained in the present screening screening results in increased Pax4 gene expression and increased insulin gene expression, which is caused by the fatigue of pancreatic beta cells, i.e., prevention of diabetes progression It is very useful as a therapeutic drug composition.

机译：本发明的筛选方法选择能够增强胰腺中Pax4基因表达的物质。 Beta。 -可用于保护胰腺β细胞免于衰竭或增强胰腺β细胞功能的细胞。另外，本筛选筛选中获得的物质和/或激活素受体激活剂导致Pax4基因表达增加和胰岛素基因表达增加，这是由胰腺β细胞的疲劳引起的，即预防糖尿病的进展。可用作治疗药物组合物。

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公开/公告号JPWO99/66073A1

专利类型
公开/公告日2002-11-26

原文格式PDF
申请/专利权人山之内製薬株式会社;
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申请/专利号JP特願2000-554881(P2000-554881)
发明设计人上田能孝;
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申请日1999-06-15
分类号C12Q1/68;A61K38/00;A61K45/00;A61P3/10;C12N15/09;G01N33/15;
国家 JP
入库时间 2022-08-22 00:21:38

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