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Variant urikaze, variant urikaze gene, manufacturing method null of new rearrangement body DNA and variant
Variant urikaze, variant urikaze gene, manufacturing method null of new rearrangement body DNA and variant
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机译：变体尿糖，变体尿糖基因，新的重排体DNA和变体的制造方法无效
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摘要
PROBLEM TO BE SOLVED: To obtain a new variant uricase gene having an amino acid sequence produced by varying amino acids at a specific site in the amino acid sequence of a wild type uricase having a specific amino acid sequence, and coding for the stabilized variant uricase useful in a clinical diagnosis field, etc. ;SOLUTION: This new gene codes for a physically and chemically stable variant uricase comprising a polypeptide containing an amino acid sequence produced by varying amino acids at the 165 to 170 sites among a wild type uricase amino acid sequence of the formula. The variant uricase is extremely useful in a clinical diagnosis field. The gene is obtained by separating the chromosomal DNA as a gene source from Candida utilis ATCC 9950 strain, cloning the DNA, isolating the gene of the wild type uricase, and subsequently varying a base sequence coding for the 165-170th amino acids among the amino acid sequence by a site-specific mutation method, etc.;COPYRIGHT: (C)1997,JPO
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