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Is detected whether or not the antibody for the mouse leukemia virus in the serum of the patient who receives gene remedy exists, the manner
Is detected whether or not the antibody for the mouse leukemia virus in the serum of the patient who receives gene remedy exists, the manner
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机译：检测接受基因治疗的患者血清中是否存在针对小鼠白血病病毒的抗体，方式
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摘要
Relates to a method of detecting (replication competent virus, RCV) a replication-competent virus from the serum of patients undergoing gene therapy, said method (57) [Abstract] The present invention, the anti-serum with a specific antigen - Retro and a step of detecting the virus antibody. Antigen gene of the present invention is not present in the gene therapy viral vectors, it is present in the viral genome where the viral vector is derived from, one of the Env protein and a portion of the Gag protein (murine leukemia virus, MLV) of murine leukemia virus be selected from the group consisting of parts is preferred. The present invention provides an antigen having the amino acid sequence of SEQ ID NO: 6 or SEQ ID NO: 2, the specificity and this immune response in terms of sensitivity - which is very useful for the detection of basic RCR.
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机译：本发明涉及一种从接受基因治疗的患者的血清中检测（复制感受态病毒，RCV）具有复制能力的病毒的方法，所述方法（57）。检测病毒抗体的步骤。本发明的抗原基因不存在于基因治疗病毒载体中，而是存在于病毒基因组所在的病毒基因组中，其中Env蛋白之一和一部分Gag蛋白（鼠白血病病毒，MLV）鼠白血病病毒中，优选的是选自下组。本发明提供了一种抗原，其具有SEQ ID NO：6或SEQ ID NO：2的氨基酸序列，就敏感性而言特异性和该免疫应答-对于检测碱性RCR非常有用。
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