首页> 外国专利> Genetically modified T cells, useful e.g. for inhibiting allogenic transplant rejection, produced by incubating recipient and donor T cells then transducing with immunomodulatory gene

Genetically modified T cells, useful e.g. for inhibiting allogenic transplant rejection, produced by incubating recipient and donor T cells then transducing with immunomodulatory gene

机译：基因修饰的T细胞，例如通过抑制受体和供体T细胞，然后通过免疫调节基因转导而产生的抑制同种异体移植排斥反应

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摘要

Genetically modified T cells (A) are produced by (i) stimulating, in vitro, T cells (A1) of a transplant recipient with cells (B1) from a transplant donor or cells (B2) that express dominant MHC (major histocompatibility complex) molecules and (ii) simultaneously or subsequently, transduction of (A1) by gene transfer of immunomodulatory, therapeutic genes (I). An Independent claim is also included for a method for producing (A).

机译：基因修饰的T细胞（A）是通过（i）用来自移植供体的细胞（B1）或表达显性MHC（主要组织相容性复合体）的细胞（B2）体外刺激移植受体的T细胞（A1）产生的分子和（ii）同时或随后通过免疫调节性治疗基因（I）的基因转移进行（A1）的转导。还包括一种用于生产（A）的方法的独立权利要求。

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公开/公告号DE10128980A1

专利类型
公开/公告日2002-01-10

原文格式PDF
申请/专利权人 UNIVERSITAETSKLINIKUM CHARITE MEDIZINISCHE FAKULTAET DER HUMBOLDT-UNIVERSITAET ZU BERLIN;
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申请/专利号DE20011028980
发明设计人 RITTER THOMAS;VOLK HANS-DIETER;HAMMER MARKUS;BRANDT CHRISTINE;SCHROEDER GRIT;LEHMANN MANFRED;FLUEGEL ALEXANDER;
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申请日2001-06-08
分类号C12N5/16;C12N15/86;
国家 DE
入库时间 2022-08-22 00:26:57

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