首页> 外国专利> RECONSTRUCTED HUMAN ANTI-HM 1,24 ANTIBODY, DNA ENCODING H- AND L-CHAIN OF HUMAN ANTI-HM 1,24 ANTIBODY, VECTOR, METHOD OF PREPARING RECONSTRUCTED HUMAN ANTI-HM 1,24 ANTIBODY, PHARMACEUTICAL COMPOSITION FOR MYELOMA TREATMENT

RECONSTRUCTED HUMAN ANTI-HM 1,24 ANTIBODY, DNA ENCODING H- AND L-CHAIN OF HUMAN ANTI-HM 1,24 ANTIBODY, VECTOR, METHOD OF PREPARING RECONSTRUCTED HUMAN ANTI-HM 1,24 ANTIBODY, PHARMACEUTICAL COMPOSITION FOR MYELOMA TREATMENT

机译：重构的人类抗HM 1,24抗体，编码人类抗HM 1,24抗体的H链和L链的DNA，载体，制备重构的人类抗HM 1,24抗体，药物组合物用于骨髓瘤治疗的方法

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FIELD: molecular biotechnology, medicine. SUBSTANCE: invention presents a reconstructed human anti-HM 1.24 antibody where C-site of H- and L-chain and V-site of H- and L-chain comprise human FR and CDR is prepared from anti-HM 1.24 monoclonal antibody and CDR shows low antigenicity. Reconstructed human anti-HM 1.24 antibody is prepared by transformation of Cell-host with expressing vector that comprises DNA encoding antibody. Human anti-HM 1.24 antibody is used as an active component for treatment of myeloma. EFFECT: improved method of preparing, valuable antitumor property. 17 cl, 40 dwg, 6 tbl

机译：领域：分子生物技术，医学。物质：本发明提出了一种重构的人抗HM 1.24抗体，其中H-和L-链的C-位点和H-和L-链的V-位点包含人FR，并且CDR由抗HM 1.24单克隆抗体和CDR制备显示低抗原性。通过用包含编码抗体的DNA的表达载体转化细胞宿主来制备重组的人抗HM 1.24抗体。人类抗HM 1.24抗体被用作治疗骨髓瘤的活性成分。效果：改进的制备方法，有价值的抗肿瘤特性。 17厘升，40桶，6桶

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公开/公告号RU2184147C2

专利类型
公开/公告日2002-06-27

原文格式PDF
申请/专利权人 CHUGAI SEJJAKU KABUSIKI KAJSJA (JP);
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申请/专利号RU19990109034
发明设计人 ONO KOJTIRO (JP);OKHTOMO TOSIKHIKO (JP);TSUTIJA MASAJUKI (JP);JOSIMURA JASUSI (JP);KOJSIKHARA JASUO (JP);KOSAKA MASAAKI (JP);
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申请日1997-10-03
分类号C12N15/13;C12N15/63;C12P21/08;C07K16/28;A61K39/395;
国家 RU
入库时间 2022-08-22 00:28:13

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