首页> 外国专利> A GENE WHOSE EXPRESSION PROMOTES DIFFERENTIATION OF MYELOID PROGENITOR CELLS INTO NEUTROPHILS AND/OR MONOCYTES/MACROPHAGES

A GENE WHOSE EXPRESSION PROMOTES DIFFERENTIATION OF MYELOID PROGENITOR CELLS INTO NEUTROPHILS AND/OR MONOCYTES/MACROPHAGES

机译：基因的表达促进骨髓祖细胞分化为中性粒细胞和/或单核细胞/巨噬细胞

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摘要

The present invention provides a human gene sequence that encodes the CDDP-1 polypeptide, which is involved in cell differentiation, in particular differentiation of undifferentiated progenitor cells into neutrophis, monocytes/macrophages, mast cells, and/or erythroid cells. Assays for detecting CDDP-1 expression, vectors that express CDDP-1, methods for using CDDP-1 to include or promote cell differentiation, and transgenic animals deficient in one or both CDDP-1 alleles are described.

机译：本发明提供了编码CDDP-1多肽的人基因序列，其参与细胞分化，特别是未分化的祖细胞分化为嗜中性粒细胞，单核细胞/巨噬细胞，肥大细胞和/或红系细胞。描述了用于检测CDDP-1表达的测定，表达CDDP-1的载体，使用CDDP-1包括或促进细胞分化的方法以及缺乏一个或两个CDDP-1等位基因的转基因动物。

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公开/公告号WO02057305A2

专利类型
公开/公告日2002-07-25

原文格式PDF
申请/专利权人 MICHIGAN STATE UNIVERSITY;
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申请/专利号WO2002US00057
发明设计人 TIAN QIANG;SCHWARTZ RICHARD C.;
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申请日2002-01-04
分类号C07K14/47;A01K67/027;C07K16/18;C12N15/12;C12Q1/68;G01N33/50;G01N33/577;
国家 WO
入库时间 2022-08-22 00:35:38

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