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Vaccine compositions comprising chitosan for mucosal administration for enhancing IgA mucosal and IgG systemic immune responses
Vaccine compositions comprising chitosan for mucosal administration for enhancing IgA mucosal and IgG systemic immune responses
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机译：包含壳聚糖的用于粘膜施用的疫苗组合物，用于增强IgA粘膜和IgG全身免疫应答
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摘要
A vaccine composition adapted for mucosal, particularly intra nasal, administration is described. The composition comprises one or more influenza vaccine antigens and an effective adjuvant amount of an acid addition salt of a chitosan wherein the chitosan is a deacetylated chitin which is at least 80 % deacetylated and has an apparent viscosity of less than 10mPas in a 1% w/v solution at 25oC in 0.9% NaCl.
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