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Dipyridoxylphosphatforbindelser, chelates thereof, NMRI contrast medium material and intermediates for the preparation of dipyridoxylphosphatforbindelserne
Dipyridoxylphosphatforbindelser, chelates thereof, NMRI contrast medium material and intermediates for the preparation of dipyridoxylphosphatforbindelserne
N,N min -bis-(pyridoxal-5-phosphate)-alkylenediamine-N,N min -diacetic acids, N,N min -bis-(pyridoxal-5-phosphate)-1,2-cycloalkylenediamine N,N min -diacetic acids, and N,N min -bis-(pyridoxal-5-phosphate)-1,2-arylenediamine-N,N min -diacetic acids, the corresponding monophosphate compounds and monoacetic acid compounds, and their salts and esters form stable, highly soluble chelates with paramagnetic metal ions, and are highly effective NMRI contrast agents. Preferred contrast agents are paramagnetic ion chelates of N,N min -bis-(pyridoxal-5-phosphate)ethylene diamine-N,N min -diacetic acid, N,N min -bis-(pyridoxal-5-phosphate)trans-1,2-cyclohexylenediamine-N,N min -diac etic acid, N,N min -bis-(pyridoxal-5-phosphate)trans-1,2-arylenediamine-N,N min -diacetic acid, and the soluble calcium salts thereof. Novel intermediates for forming these compounds are N,N min -bis(pyridoxal-5-phosphate)alkylenediimines, N,N min -bis(pyridoxal-5-phosphate)alkylenediamines, N,N min -bis(pyridoxal-5-phosphate)-1,2-cycloalkylenediimines, N,N min -bis(pyridoxal-5-phosphate)-1,2-cycloalkylenediamines, N,N min -bis(pyridoxal-5-phosphate)-1,2-arylenediamines, and the corresponding monophosphate compounds.
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