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首页> 外国专利> Methods of inducing an immune response against an immunogen in an individual, reducing rejection of unlike donor cells, tissue or organ in an individual and a dominant immune response in an individual and expanding a subpopulation of t cells associated with an immune response specifically, plasmid and composition

Methods of inducing an immune response against an immunogen in an individual, reducing rejection of unlike donor cells, tissue or organ in an individual and a dominant immune response in an individual and expanding a subpopulation of t cells associated with an immune response specifically, plasmid and composition

机译：诱导个体中针对免疫原的免疫反应，减少个体中不同的供体细胞，组织或器官的排斥以及个体中显性免疫反应并扩大与免疫反应相关的t细胞亚群的方法，特别是质粒和组成

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"METHODS OF INDUCING AN IMMUNOLOGICAL RESPONSE AGAINST AN IMMUNOGENE IN AN INDIVIDUAL, OF REDUCING DISPOSAL OF CELLS, TISSUE OR NON-SIMILAR DONOR ORGANIZATION IN A INDIVIDUAL AND A RESPONSE OF A UNMOMINATED UNION IN A UNIQUE UNION SPECIFICALLY IMMUNOLOGICAL, PLASMID, AND, COMPOSITION ". There are methods of inducing an immune response against an immunogen in an individual. The methods comprise administering to the individual one or more nucleic acid molecules that comprise a nucleotide sequence that encodes an immunogen and a nucleotide sequence that encodes a major histocompatibility complex antigen. The nucleotide sequences encoding the immunogen and the major histocompatibility complex antigen are expressed when absorbed by the individual's cells, and an immune response against the immunogen is induced in the individual. Methods to reduce rejection of unrelated donor cells, tissue or organs are disclosed in an individual who is undergoing cell, tissue or organ transplantation. The methods comprise administering to the individual, one or more nueleic acid molecules that comprise a nucleotide sequence that encodes a death or toxin signal and a nucleotide sequence that encodes a major histocompatibility complex antigen that is similar to cells, tissue or donor organ. The nucleotide sequences that encode the major histocompatibility complex antigen and signal of death or toxin are expressed when absorbed by the individual's cells. The death of T cells through interaction with the death signal or toxin results in a reduction in rejection of non-similar donor cells, tissue or organ. Methods for reducing a dominant immune response in an individual are also described. Methods for expanding a subpopulation of T cells associated with a specific immune response. Plasmids and compositions comprising plasmids useful for practicing the method are described.
机译：“在个体中引起针对免疫原性的免疫反应的方法，减少个体中细胞，组织或非类似的捐赠者组织的处置，并在统一的统一体中以统一，统一的方式在统一的，统一的，统一的，统一的组织上做出反应。存在在个体中诱导针对免疫原的免疫应答的方法。所述方法包括向个体施用一种或多种核酸分子，所述核酸分子包含编码免疫原的核苷酸序列和编码主要组织相容性复合抗原的核苷酸序列。当被个体细胞吸收时，表达编码免疫原和主要组织相容性复合抗原的核苷酸序列，并且在个体中诱导出针对免疫原的免疫应答。在正在进行细胞，组织或器官移植的个体中公开了减少不相关的供体细胞，组织或器官的排斥的方法。该方法包括向个体施用一种或多种核酸分子，其包含编码死亡或毒素信号的核苷酸序列和编码与细胞，组织或供体器官相似的主要组织相容性复合抗原的核苷酸序列。当被个体细胞吸收时，会表达编码主要组织相容性复合抗原和死亡或毒素信号的核苷酸序列。 T细胞通过与死亡信号或毒素相互作用而死亡，导致非相似供体细胞，组织或器官的排斥反应减少。还描述了减少个体中显性免疫反应的方法。扩大与特定免疫反应相关的T细胞亚群的方法。描述了用于实施该方法的质粒和包含质粒的组合物。

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