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SODIUM MAGNETIC RESONANCE IMAGING USED IN DIAGNOSING TUMORS AND ASSESSING RESPONSE TO TREATMENT
SODIUM MAGNETIC RESONANCE IMAGING USED IN DIAGNOSING TUMORS AND ASSESSING RESPONSE TO TREATMENT
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机译：钠磁共振成像用于诊断肿瘤及评估对治疗的反应
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摘要
The present invention provides a method for acquiring magnetic resonance data from a sample by: a) applying a radio frequency pulse to a sample in a magnetic field, thereby causing alignment of nuclei populations within the sample, b) applying a radio frequency pulse at a set time interval (TI), thereby causing a measurable signal in the transverse plane, c) suppressing a nuclei population in the sample by suitably selecting TI or by applying a multiple quantum filter, d) applying image encoding or multiple quantum filters to the sample in (a), e) detecting and analyzing the output signal to obtain a weighted image, f) applying the magnetic field to the sample in (a), g) detecting and analyzing the output signal to obtain an unweighted image, and h) comparing the weighted and unweighted images. The present invention also provides a method of determining the effectiveness of chemotherapy, detecting and characterizing tumors or determining cell death or cellular dysfunction by administering a dose of antineoplastic agent to a subject prior to surgical removal of a cancerous tumor and applying the method for acquiring magnetic resonance data to determine if the antineoplastic agent has altered the nuclei populations in a subject.
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