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Isolation and characterisation of receptors that are bound by members of the BT-toxin family of insecticidal proteins with respect to pesticides and pest resistance
Isolation and characterisation of receptors that are bound by members of the BT-toxin family of insecticidal proteins with respect to pesticides and pest resistance
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机译：关于杀虫剂和害虫抗性的与杀虫蛋白BT-毒素家族成员结合的受体的分离和鉴定
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摘要
The cDNA encoding a glycoprotein receptor from the tobacco hornworm (Manduca sexta) that binds a Bacillus thuringiensis (BT) toxin has been obtained and sequenced. The availability of this cDNA permits the retrieval of DNAs encoding homologous receptors in other insects and organisms as well as the design of assays for the cytotoxicity and binding affinity of potential pesticides and the development of methods to manipulate natural and/or introduced homologous receptors and thus, to destroy target cells, tissues and/or organisms. The isolation and characterisation of a receptor that is bound by members of the BT-toxin family of insecticidal proteins (BT-R1 protein) and a gene encoding the BT-toxin receptor are described. Compositions and methods for use in identifying agents that bind to the BT-R1 protein as a means for identifying insecticidal agents and for identifying other members of the BT-R1 family are also described.
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