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Temperature and pH stable lanthionine based mutacin antibiotic compositions and methods derived from Streptococcus mutans
Temperature and pH stable lanthionine based mutacin antibiotic compositions and methods derived from Streptococcus mutans
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机译：源自变形链球菌的温度和pH值稳定的基于羊毛硫氨酸的诱变剂抗生素组合物和方法
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摘要
Certain bacteria indigenous to humans produce antimicrobial substances called bacteriocins that inhibit other bacteria, including members of their own species. Mutacins are a class of antibiotic substances made by Streptococcus mutans. Disclosed is the purification and biochemical characterization of a novel lanthionine-containing mutacin peptide from S. mutans. The purified peptide is pH- and temperature-stable and its amino acid composition indicates the presence of lanthionine and beta -methyllanthionine. Also provided are methods of making and using the purified polypeptide.
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