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Method for regulating nicotine metabolism through inhibition of CYP2A6 and CYP2B6 liver enzymes

机译：通过抑制CYP2A6和CYP2B6肝酶调节尼古丁代谢的方法

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摘要

Described is the use of a substance which selectively inhibits human cytochrome P450 2A6 for the preparation of a medicament for treating a condition requiring regulation of nicotine metabolism to cotinine in an individual. Also described is an in vitro method of screening for a substance that regulates nicotine metabolism to cotinine in an individual comprising assaying for a substance which (i) selectively inhibits human cytochrome P450 2A6 activity, or (ii) selectively inhibits transcription and/or translation of the gene encoding human cytochrome P450 2A6.

机译：描述了选择性抑制人细胞色素P450 2A6的物质在制备药物中的用途，该药物用于治疗需要调节烟碱代谢成个体中可替宁的疾病。还描述了在个体中筛选调节烟碱代谢成可替宁的物质的体外方法，包括测定（i）选择性抑制人细胞色素P450 2A6活性，或（ii）选择性抑制尼古丁的转录和/或翻译的物质。编码人细胞色素P450 2A6的基因。

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公开/公告号NZ334205A

专利类型
公开/公告日2001-04-27

原文格式PDF
申请/专利权人 NICOGEN INC;
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申请/专利号NZ19970334205
发明设计人 SELLERS EDWARD M;TYNDALE RACHEL F;
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申请日1997-07-17
分类号A61K31/44;A61K31/12;A61K31/37;A61K31/415;A61K31/13;A61K31/27;A61K31/70;
国家 NZ
入库时间 2022-08-22 01:24:16

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