首页> 外国专利> Altered pneumolysin, vaccine containing the altered pneumolysin, recombinant plasmid encoding the altered pneumolysin, hybrid host cell containing the recombinant plasmid, methods of producing the altered ........

Altered pneumolysin, vaccine containing the altered pneumolysin, recombinant plasmid encoding the altered pneumolysin, hybrid host cell containing the recombinant plasmid, methods of producing the altered ........

机译：改变的肺炎球菌溶血素，含有改变的肺炎球菌溶血素的疫苗，编码改变的肺炎球菌溶血素的重组质粒，含有重组质粒的杂种宿主细胞，产生改变的.....的方法。

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摘要

Mutants of pneumolysin that are non-toxic by reason of amino acid substitutions have been constructed. These mutants elicit an immune response in animals that is reactive to wild-type pneumolysin. The invention also encompasses vaccines for humans based on these mutants, including vaccines comprising conjugates with pneumococcal capsular polysaccharides.

机译：已经构建了由于氨基酸取代而无毒的肺炎球菌溶血素突变体。这些突变体在动物中引发对野生型肺炎球菌溶血素的反应。本发明还包括基于这些突变体的人类疫苗，包括包含与肺炎球菌荚膜多糖缀合物的疫苗。

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公开/公告号DK173629B1

专利类型
公开/公告日2001-05-14

原文格式PDF
申请/专利权人 DE STAAT DER NEDERLANDEN VERTEGENWOORDIGD DOOR DE MINISTER VAN WELZIJN VOLKSGESONDHEID EN CULTUUR;
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申请/专利号DK19910001155
发明设计人 PATON JAMES CLELAND;HANSMAN DAVID JOHN;BOULNOIS GRAHAM JOHN;ANDREW PETER WILLIAM;MITCHELL TIMOTHY JOHN;WALKER JOHN ARTHUR;
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申请日1991-06-14
分类号C07K14/315;A61K39/09;C12N15/31;
国家 DK
入库时间 2022-08-22 01:25:39

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