首页> 外国专利> Analog of covalently reactive antigen (craa), processes to treat a disease state in a patient irreversibly inhibiting the action of a catalytic antibody, and to stimulate the production of antibodies with catalytic activity, catalytic antibody, processes to treat a state of disease in a patient, to inhibit the catalytic antibody, and to passively immunize a patient, and, pharmaceutical preparation to treat a pathological condition related to the presence of endogenously produced catalytic antibodies

Analog of covalently reactive antigen (craa), processes to treat a disease state in a patient irreversibly inhibiting the action of a catalytic antibody, and to stimulate the production of antibodies with catalytic activity, catalytic antibody, processes to treat a state of disease in a patient, to inhibit the catalytic antibody, and to passively immunize a patient, and, pharmaceutical preparation to treat a pathological condition related to the presence of endogenously produced catalytic antibodies

机译：共价反应性抗原（craa）的类似物，用于治疗不可逆转地抑制催化抗体作用的患者疾病状态，并刺激具有催化活性的抗体的产生的方法，催化抗体，用于治疗患者疾病状态的方法。患者，以抑制催化抗体并被动免疫患者，以及药物制剂，用于治疗与内源性产生的催化抗体的存在有关的病理状况

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"ANALOGUE OF COVALENTALLY REACTIVE ANTIGEN (CRAA), PROCESSES TO TREAT A STATE OF DISEASE IN A PATIENT IRREVERSIVELY INHIBITING THE ACTION OF A CATALYTIC ANTIBODY, AND TO STIMULATE THE PRODUCTION OF ACTIVATELY, ACTIVATELY, CATALYTIC ANTIBODY, ACTIVELY ACTIVATIVELY ACTIVATELY ACTIVATELY, ACTIVELY ACTIVATELY ACTIVE OF DISEASE IN A PATIENT, TO INHIBIT THE CATALYTIC ANTIBODY, AND TO PASSIVELY IMMUNIZE A PATIENT, AND PHARMACEUTICAL PREPARATION TO TREAT A PATHOLOGICAL CONDITION RELATED TO THE PRESENCE OF ENDOGENALLY PRODUCED CATALYTIC ANTIBODIES ". Covalently reactive antigen analogs are disclosed herein. The antigens of the invention can be used to stimulate the production of specific catalytic antibodies to predetermined antigens, associated with particular medical disorders. Antigen analogs can also be used to permanently inactivate endogenously produced catalytic antibodies, produced in certain autoimmune diseases as well as in certain lymphoproliferative disorders.

机译：“同价反应性抗原（CRAA）的类似物，用于在患者中不可逆转地抑制催化抗体的作用，并刺激活性，活化，活化，活性，活性，活性的产生的疾病状态的过程病，以抑制催化抗体，并被动免疫患者，并进行药物治疗以治疗与内源性产生的催化抗体有关的病理情况。”本文公开了共价反应性抗原类似物。本发明的抗原可用于刺激针对预定抗原的特异性催化抗体的产生，该抗体与特定的医学病症有关。抗原类似物还可用于永久灭活在某些自身免疫性疾病以及某些淋巴增生性疾病中产生的内源产生的催化抗体。

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公开/公告号BR9909011A

专利类型
公开/公告日2000-11-28

原文格式PDF
申请/专利权人 UNIVERSITY OF NEBRASKA BOARD OF REGENTS;
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申请/专利号BR19999909011
发明设计人 SUDHIR PAUL;GENNADY GOLOLOBOV;LARRY SMITH;
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申请日1999-03-23
分类号C07K16/00;
国家 BR
入库时间 2022-08-22 01:26:00

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