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Retroviral vector, a replication system for said vector and avian or mammalian cells transfected with said vector
Retroviral vector, a replication system for said vector and avian or mammalian cells transfected with said vector
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机译:逆转录病毒载体,所述载体和用所述载体转染的禽或哺乳动物细胞的复制系统
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摘要
A retroviral vector comprising a retrovirus with infectivity for birds and/or mammals in which at least part of the genomic RNA sequences carrying information for the production of viral proteins required in trans for retroviral replication have been replaced by one or more sequences carrying information to be introduced in a target cell chromosome, characterized in that the primer binding site (PBS) has been modified to a sequence that does not allow strong base pairing with the 3' end or other priming sequence in any naturally occurring tRNA. The present application is directed to the tRNA-like primer.
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