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A method for the production of 20 - oxo, 17 - alpha, 21 - dihydroxy steroids derivatives and new intermediates therefor
A method for the production of 20 - oxo, 17 - alpha, 21 - dihydroxy steroids derivatives and new intermediates therefor
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机译:一种生产20-氧,17-α,21-二羟基类固醇衍生物的方法及其新中间体
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摘要
The invention relates to a process for preparing the compounds (i): & br / (see appended drawing in bopi) & br / in which r1 is hydrogen or alkyl, r2 is alkyl, and the rings a, b, c and d have one or more double bonds and optionally one or more hydroxyl functional groups or ketone, the case may be protected, one or more halogen atoms or one or more alkyl, alkoxy, alkenyl or alkynyl, a process consisting essentially of an adduct epimerize 17 alpha - oh obtained by the action of lithio vinylene acetonide on a steroid 17 - acid, in the derivative 17 alpha - oh via a double allyl rearrangement sulfenate / allylic sulfoxides and to hydrolyse the latter in corticosteroid of configuration naturelle.l' invention further relates to novel intermediates thus obtained.
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