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Polymorphisms in the human alpha4 integrin subunit gene, suitable for diagnosis and treatment of integrin ligand mediated diseases
Polymorphisms in the human alpha4 integrin subunit gene, suitable for diagnosis and treatment of integrin ligand mediated diseases
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机译:人类alpha4整合素亚基基因中的多态性,适用于诊断和治疗整合素配体介导的疾病
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摘要
This invention relates to polymorphisms in the human alpha 4 integrin subunit gene, in particular the invention is based on the discovery of five single nucleotide polymorphisms (SNPs) in the coding region of the human alpha 4 integrin subunit gene and eight in the promoter region. The invention also relates to methods and materials for analysing allelic variation in the alpha 4 integrin subunit gene, and to the use of alpha 4 integrin subunit polymorphism in the diagnosis and treatment of integrin ligand mediated diseases such as multiple sclerosis, rheumatoid arthritis, atherosclerosis and allergic asthma.
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