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Method and composition for the regulation of hepatic and extrahepatic productionof insulin-like growth factor-1
Method and composition for the regulation of hepatic and extrahepatic productionof insulin-like growth factor-1
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机译:调节胰岛素样生长因子-1肝和肝外产生的方法和组合物
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摘要
Method for separately regulating hepatic and extrahepatic production and insulin-like growth factor-1 (IGF-1). The levels of IGF-1 in sera can be significantly reduced without reducingt the desired actions of IGF-1. This is achieved by separately regulating the systemic and local distribution of IGF-1 without affecting body growth. The invention also relates to the treatment of obesity. It further refers to the treatment of retinopathy in diabetic patients. Inhibition of the biological effects exerted by IGF-I in blood circulation could be obtained by injection of IGF-I antagonists, IGF binding proteins, or thyrohostins into blood circulation or by blockade of hepatic IGF-I information, for instance by oral treatment with estrogenic agents or by local treatment with small nucleotide molecules.
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