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Method and composition for the regulation of hepatic and extrahepatic productionof insulin-like growth factor-1

机译:调节胰岛素样生长因子-1肝和肝外产生的方法和组合物

摘要

Method for separately regulating hepatic and extrahepatic production and insulin-like growth factor-1 (IGF-1). The levels of IGF-1 in sera can be significantly reduced without reducingt the desired actions of IGF-1. This is achieved by separately regulating the systemic and local distribution of IGF-1 without affecting body growth. The invention also relates to the treatment of obesity. It further refers to the treatment of retinopathy in diabetic patients. Inhibition of the biological effects exerted by IGF-I in blood circulation could be obtained by injection of IGF-I antagonists, IGF binding proteins, or thyrohostins into blood circulation or by blockade of hepatic IGF-I information, for instance by oral treatment with estrogenic agents or by local treatment with small nucleotide molecules.
机译:分别调节肝外生产和胰岛素样生长因子-1(IGF-1)的方法。可以显着降低血清中IGF-1的水平,而无需降低IGF-1的预期作用。这是通过分别调节IGF-1的全身和局部分布而不影响人体生长来实现的。本发明还涉及肥胖症的治疗。它还涉及糖尿病患者的视网膜病变的治疗。可以通过向血液循环中注射IGF-1拮抗剂,IGF结合蛋白或甲状腺原蛋白或通过阻断肝IGF-1信息来抑制IGF-1在血液循环中的生物学作用,例如通过口服雌激素治疗药物或通过小核苷酸分子局部治疗。

著录项

  • 公开/公告号AU3579200A

    专利类型

  • 公开/公告日2000-09-14

    原文格式PDF

  • 申请/专利权人 SALTECH I GOTEBORG AB;

    申请/专利号AU20000035792

  • 申请日2000-02-28

  • 分类号A61K38/30;A61K31/565;A61P3/04;A61P35/00;

  • 国家 AU

  • 入库时间 2022-08-22 01:51:57

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