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SUBSTITUTED 4-ARYLMETHYLENE-2-IMINO-2,3-DIHYDROTHIAZOLES, THEIR DERIVATIVES AND APPLICATION IN THE PHARMACEUTICAL INDUSTRY
SUBSTITUTED 4-ARYLMETHYLENE-2-IMINO-2,3-DIHYDROTHIAZOLES, THEIR DERIVATIVES AND APPLICATION IN THE PHARMACEUTICAL INDUSTRY
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机译：取代的4-芳基亚甲基-2-亚氨基-2,3-二氢噻唑及其衍生物和在医药工业中的应用
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摘要
The compounds, including their pharmaceutically acceptable salts in the form of individual enantiomers, racemates and other enantiomer mixtures have the general formula where Ar is phenyl, naphthyl or benzo(b)thiophenyl each of which can optionally be substituted; R1 & R2 can be the same or different meaning individually H, alkyl group with 1 to 6 carbon atoms, alkenyl group with 3 to 6 carbon atoms, cycloalkyl group with 3 to 7 carbon atoms, cycloalkylmethyl group the ring of which is with 3 to 7 carbon atoms, aryl or heteroaryl group, optionally substituted, arylalkyl or heteroarylalkyl group, optionally substituted, or R1 and R2 form alkylene chain optionally substituted with one or more alkyl group with 1 to 3 carbon atoms so that together with the atoms to which they are adjuncted can form 5- or 6-member ring, R3 is H, aryl or heteroaryl group, optionally substituted, arylmethyl group optionally substituted, or alkoxyalkyl group with 3 to 6 carbon atoms, and R4 & R5 can be the same or different and individually mean alkyl group with 1 to 3 carbon atoms, and R4 & R5 together with the atom to which they are adjuncted, form cycloalkyl ring containing 3 to 6 carbon atoms. The invention also relates to a method for the preparation of the above compounds, to compositions containing them and to their application for the treatment of depression, anxiety, Parkinson, neurological disease and as a neuroprotective means. 17 claims
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