首页>
外国专利>
A method to identify agents that bind to a receptor of BT toxin, and that block the binding of an Antibody to a BT toxin; isolated; a proteinareceptora isolation of BT toxin and a method for PRoducirla
A method to identify agents that bind to a receptor of BT toxin, and that block the binding of an Antibody to a BT toxin; isolated; a proteinareceptora isolation of BT toxin and a method for PRoducirla
Method to identify agents that bind to a receptor of BT toxin, which comprises the following steps: (i) contacting an agent that binds with unreceptor BT toxinSelected from the group consisting of (a) a cell that has been altered to contain a Nucleic Acid Molecule that cocodifica for Amino Acid Sequence SEQ ID no: 2(b) a cell that has been altered to contain a Nucleic Acid Molecule that encodes a moderate fragment sequence of SEQ ID no: 2(c) a cell that has been altered to contain a Nucleic Acid Molecule that encodes for a receptor of BT toxin hidridiza with the sequence of SEQ ID no: 1 in a very estrictAs,(d) a cell that has been altered to conteneruna Nucleic Acid Molecule which encodes for a receptor of BT toxin fragment that hybridizes with the sequence of SEQ ID no: 1 in the conditionGoods or services that meettough and is joined to the BT toxin, (e) isolated a Protein with the Amino Acid Sequence SEQ ID no: 2, (f) isolated a Protein Fragment of the sequence SEQ ID no: 2Fragment that contains the binding domain to the BT toxin.(g) an isolated Receptor of BT toxin codificadopor is a Nucleic Acid Molecule that hybridizes with the sequence of SEQ ID no: 1 under very strict conditions.And (H) a single Fragment of the Receptor of BT toxin, which is encoded by a Nucleic Acid Molecule that hybridizes with the sequence of SEQ ID no: 1 under very strict conditions.And determine sidicho Agent binds to this Receptor of BT toxin.Other Objects of the invention are a method to identify agents that block the binding of an Antibody to BT toxin; isolation; isolation of BT toxin a receptor protein and a method for producingRLA.
展开▼
机译：鉴定与BT毒素的受体结合的药物的方法，其包括以下步骤：（i）使与非受体BT毒素结合的药物接触选自（a）已被改变为包含核酸的细胞编码氨基酸序列SEQ ID no：2（b）的分子已被改变为包含编码SEQ ID no：2（c）的中等片段序列的核酸分子的细胞已被改变为包含在非常严格的条件下，编码具有SEQ ID no：1序列的BT毒素Hidridiza受体的核酸分子;（d）已被改变为conteneruna核酸分子的细胞，其编码BT毒素片段的受体在满足条件的商品或服务中与SEQ ID No：1的序列杂交并与BT毒素结合的（e）分离出具有SEQ ID no：2的氨基酸序列的蛋白（f）分离出一个蛋白片段SEQ ID NO：2的片段帽子包含与BT毒素的结合域。（g）BT毒素codificadopor的分离受体是一种核酸分子，在非常严格的条件下与SEQ ID no：1的序列杂交。并且（H）由核酸分子编码的BT毒素的受体在非常严格的条件下与SEQ ID no：1的序列杂交，并确定sidicho Agent与该BT毒素的受体结合。本发明的其他目的是一种鉴定能阻止抗体与BT毒素结合的试剂;隔离; BT毒素a受体蛋白的分离和产生RLA的方法。
展开▼
