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The recombinant microorganism expressing the antigen protein UreB of Hericobacter pylori
The recombinant microorganism expressing the antigen protein UreB of Hericobacter pylori
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机译：表达幽门螺杆菌抗原蛋白UreB的重组微生物
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摘要
The present invention provides a fusion gene in which the A2 / B subunit gene among the antigen protein UreB (urease B subunit) gene of Helicobacter pylori and the toxin gene of Vibrio cholerae bacteria is linked A method for producing a chimeric protein fused with an A2 / B subunit of UreB and Vibrio choloritoxin of Helicobacter pylori using an expression vector containing the same, a recombinant microorganism transformed therewith, and an electrophoresis vector will be. The recombinant DNA is artificially designed to facilitate its expression and genetic manipulation, exhibits excellent immunogenicity against Helicobacter pylori, is stable in the gastric environment, easily permeable to gastric mucosa and secretory immunoglobulin (sIgA) And a gene that provides a protein capable of promoting the production of the gene. Therefore, the chimeric protein expressed from such a recombinant DNA can be used as an effective ingredient in the production of a diagnostic reagent for Helicobacter pyrolysis or a vaccine for the prophylactic or therapeutic treatment of a disease associated with Helicobacter pylori, It can also be used for antibody production.
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