首页> 外国专利> Process for R(+)1,2,3,6-tetrahydro-4-phenyl-1-(3-phenyl-3-cyclohexen-1-il)methilpyridine, a central nervous system agent A process for R(+)1,2,3,6-tetrahydro-4-phenyl-1-(3-phenyl-3-cyclohexen-1-il)methilpyridine by a novel synthesis is described where 5-oxo-3-phenil-3-cyclohexene-carboxylic acid is converted

Process for R(+)1,2,3,6-tetrahydro-4-phenyl-1-(3-phenyl-3-cyclohexen-1-il)methilpyridine, a central nervous system agent A process for R(+)1,2,3,6-tetrahydro-4-phenyl-1-(3-phenyl-3-cyclohexen-1-il)methilpyridine by a novel synthesis is described where 5-oxo-3-phenil-3-cyclohexene-carboxylic acid is converted

机译：R（+）1,2,3,6-四氢-4-苯基-1-[（（3-苯基-3-环己烯-1-基）甲氧基]吡啶，中枢神经系统制剂的方法R（ +）1,2,3,6-四氢-4-苯基-1-[（（3-苯基-3-环己烯-1-基）甲基]吡啶]通过新颖的合成方法进行了描述，其中5-oxo-3-phenil- 3-环己烯-羧酸被转化

页面导航

摘要
著录项
相似文献

摘要

An improved process for the preparation of R(+)1,2,3,6-tetrahydro-4-phenyl-1-[(3-phenyl-3-cyclohexen-1-yl)methyl]pyridine by a novel synthesis is described where 5-oxo-3-phenyl-3-cyclohexene-carboxylic acid is converted in five operations to the desired product, as well as processes for the resolution of 5-oxo-3-phenyl-3-cyclohexenecarboxylic acid using cinchonidine to afford (S)5-oxo-3-phenyl-3-cyclohexenecarboylic acid or alpha -chymotrypsin to selectively hydrolyze n-butyl 5-oxo-3-phenyl-3-cycohexenecarboxylate to afford (S)5-oxo-3-phenyl-3-cyclohexenecarboxylic acid as well as other valuable intermediates used in the processes.

机译：描述了一种通过新型合成方法制备R（+）1,2,3,6-四氢-4-苯基-1-[（3-苯基-3-环己烯-1-基）甲基]吡啶的改进方法其中将5-氧代-3-苯基-3-环己烯羧酸在五次操作中转化为所需的产物，以及使用辛可尼定拆分5-氧代-3-苯基-3-环己烯羧酸的方法，得到（ S）5-氧代-3-苯基-3-环己烯羧酸或α-胰凝乳蛋白酶选择性水解5-氧代-3-苯基-3-环己烯羧酸正丁酯，得到（S）5-氧代-3-苯基-3-环己烯羧酸以及该方法中使用的其他有价值的中间体。

著录项

公开/公告号MD970146A

专利类型
公开/公告日1999-02-28

原文格式PDF
申请/专利权人 WARNER-LAMBERT COMPANY;
展开▼

申请/专利号MD19970000146
发明设计人 BUTLER DONALD EUGENE;GAILEY JODETTE;LE TUNG VAN;SMITH WILLIAM JOHN III;WUSTROW DAVID JUERGEN;
展开▼

申请日1995-07-28
分类号C07D211/70;C07C61/39;C07C69/757;
国家 MD
入库时间 2022-08-22 02:27:03

相似文献

专利
外文文献
中文文献