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Method for regulating inflammation and tumor growth with calmodulin, calmodulin analogues or calmodulin antagonists

机译:用钙调蛋白,钙调蛋白类似物或钙调蛋白拮抗剂调节炎症和肿瘤生长的方法

摘要

A method of treating patients to inhibit inflammation is disclosed. In the method, an effective amount of calmodulin, a calmodulin analogue or calmodulin receptor agonist is administered to a patient to inhibit production of tumor necrosis factor and/or augment elastase. In another method, an effective amount of calmodulin antagonist is administered to a patient to stimulate immune response or inhibit elastase release. In another embodiment, a diagnostic test is disclosed to be used on patient blood samples to determine individual propensity to regulate tumor necrosis factor and/or elastase by calmodulin, its analogues or receptor agonists.
机译:公开了一种治疗患者以抑制炎症的方法。在该方法中,将有效量的钙调蛋白,钙调蛋白类似物或钙调蛋白受体激动剂施用于患者以抑制肿瘤坏死因子的产生和/或增加弹性蛋白酶。在另一种方法中,将有效量的钙调蛋白拮抗剂施用于患者以刺激免疫反应或抑制弹性蛋白酶的释放。在另一个实施方案中,公开了一种诊断测试,用于对患者的血液样品进行测定,以确定通过钙调蛋白,其类似物或受体激动剂调节肿瘤坏死因子和/或弹性蛋白酶的个体倾向。

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