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Remedy medicine null of macular hole and retina fissure
Remedy medicine null of macular hole and retina fissure
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机译：黄斑裂孔和视网膜裂孔的治疗药物无效
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摘要
PURPOSE:To obtain a therapeutic agent containing epidermal growth factor(EGF) as the active component and useful for therapy of macular circular hole and retina lacuna. CONSTITUTION:This therapeutic agent contains 1 to 5wt.%, preferably 1 to 2wt.% EGF as the active component. As the active component EGF, purified natural EGF or a natural type EGF synthesized according to the gene engineering method, etc., may be used. This EGF used as the active component may also be an EGF derivative obtained by partly denaturating (substitution, deficiency, addition, etc.) the amino acid sequence constituting these natural type EGF and having the biological activity essential to the natural type EGF. Therapy the therapeutic agent is used by bringing the EGF as the active component into contact with a lesion site and generally used by a combined treatment in an operation of the vitreous body, by allowing the therapeutic agent to stay in the lesion site according to the local injection method, etc. This agent is recommendably administrated so that 0.5 to 5mug EGF may be brought into contact with the lesion at least for about 5 to 10min.
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