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Monitoring method of renal lesions without clinical signs
Monitoring method of renal lesions without clinical signs
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机译：无临床症状的肾脏病变的监测方法
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摘要
A screening method for detecting renal lesions in diabetic patients not yet exhibiting symptoms of nephropathy, comprising administering a predetermined dose of parathyroid hormone, analogue thereof or derivative thereof to the patients with an albumin excretion rate (AER) of microalbumin being below 15 &mgr;g/min., measuring urinary excreted N- acetyl-&bgr;-D-glucosaminidase (NAG) and urinary creatinine in urinary samples taken 60.+-.10 minutes before and after administration of PTH, and monitoring the increased ratio of urinary excreted NAG (U/g Cr) in post-administration of PTH to the urinary excreted NAG (U/g Cr) in pre- administration of PTH for a value less than 2.3. The screening method provides the possibility of detecting renal lesions without clinical signs of diabetic nephropathy, using a preparation essentially consisting of active ingredient of PTH.
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机译：在尚未表现出肾病症状的糖尿病患者中检测肾脏病变的筛查方法，包括将预定剂量的甲状旁腺激素，其类似物或其衍生物施用于微量白蛋白的白蛋白排泄率（AER）低于15μg的患者/ min。，在施用PTH前后60。+-。10分钟测量尿样中尿N-乙酰-b-D-氨基葡萄糖苷酶（NAG）和尿肌酐的水平，并监测尿NAG的增加比例PTH给药前尿液中排泄的NAG中的U（g / Cr）（U / g Cr）小于2.3。所述筛选方法提供了使用基本上由PTH的活性成分组成的制剂来检测没有糖尿病性肾病临床症状的肾脏病变的可能性。
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