首页> 外国专利> Pharmaceutical formulations containing penicillin inhibiting beta-lactamase in combination with beta-lactam antibiotics and methods of using the formulations in the treatment of bacterial infections. (PHARMACEUTICAL FORMULATIONS CONTAINING A BETA-LACTAMASE INHIBITING PENEM IN COMBINATION WITH A BETA-LACTAM ANTIBIOTIC AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIONS

Pharmaceutical formulations containing penicillin inhibiting beta-lactamase in combination with beta-lactam antibiotics and methods of using the formulations in the treatment of bacterial infections. (PHARMACEUTICAL FORMULATIONS CONTAINING A BETA-LACTAMASE INHIBITING PENEM IN COMBINATION WITH A BETA-LACTAM ANTIBIOTIC AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIONS

机译：含有抑制青霉素β-内酰胺酶和β-内酰胺类抗生素的药物制剂，以及使用该制剂治疗细菌感染的方法。（包含β-内酰胺酶抑制基因与β-内酰胺抗生素组合的药物配方及其在细菌感染治疗中的用途

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摘要

The present invention relates to a pharmaceutical composition comprising a pharmaceutically acceptable carrier in combination with a phenem of formula (I) and a pharmaceutically acceptable carrier selected from the group consisting of ceftazidime, cefotaxim, amoxycillin and piperacillin And a pharmaceutically acceptable derivative thereof, wherein, in the above formula (I), R is selected from the group consisting of R^OneIs hydrogen or an organic substituent and R²Is a fused double ring heterocyclic system of formula (a), wherein in formula (a), R⁴And R⁵M is 2 or 3, p is 0, 1 or 2, R 1 is hydrogen or one or more substituents which substitute hydrogen atoms in the ring system,³Is a hydrogen, a salt-forming cation or an ester-forming group, and the symbol = / = is an E or Z arrangement of double bonds.

机译：本发明涉及药物组合物，其包含与式（I）的苯酚组合的药学上可接受的载体和选自头孢他啶，头孢噻肟，阿莫西林和哌拉西林的药学上可接受的载体及其药学上可接受的衍生物，其中，在上式（I）中，R 2选自氢或有机取代基，R 2是分子式为稠合的双环杂环系统。（a），其中在式（a）中，R ^{4 和R ^{5 M是2或3，p是0、1或2，R <1>是氢或一个或多个取代环系统中氢原子的取代基，^{3 是氢，成盐阳离子或成酯基，符号= / =为E或Z排列双键。}}}

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公开/公告号KR1019977002723A

专利类型
公开/公告日1997-06-10

原文格式PDF
申请/专利权人 데이비드 로버츠;
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申请/专利号KR1019960706126
发明设计人 케네쓰 콜만;제인 엘리자베쓰 닐;
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申请日1996-10-25
分类号A61K31/545;A61K31/43;A61K31/54;
国家 KR
入库时间 2022-08-22 03:19:03

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