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首页> 外国专利> CDNA sequence, amino-acid sequence, derived from the CDNA sequence, of the precursor protein of human GCAP-II/uroguanyline, and amino-acid sequence of the fragment circulating in human blood

CDNA sequence, amino-acid sequence, derived from the CDNA sequence, of the precursor protein of human GCAP-II/uroguanyline, and amino-acid sequence of the fragment circulating in human blood

机译：人GCAP-II /尿鸟嘌呤前体蛋白的CDNA序列，源自CDNA序列的氨基酸序列以及人血中循环的片段的氨基酸序列

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摘要

The invention concerns a peptide from human blood, designated GCAP-II (guanylate cyclase activating peptide), the structure of which has been elucidated for the use of the substance as a drug for diagnostic, medical and industrial purposes. The isolation of the GCAP-II peptide proves its existence. The removal of certain amino acids from GCAP-II reduces its biological effectiveness. The GCAP-II circulating in human blood is identical to the synthetic GCAP-II reference substance, but not to other peptides or its fragments. The molecular formula of GCAP-II has been found using mass spectrometry. A different biological activity and differences in the three-dimensional peptide structure of GCAP-II compared with other GCAP-II fragments show that this GCAP-II fragment is a high-quality natural peptide belonging to a family with a peptide group which is suitable for use in treating numerous conditions which progress hand in hand with electrolyte-transport disorders in cells as well as for use in treating, in particular, diseases of endocrine organs. In addition, GCAP-II can be used industrially as the natural raw extract, or in purified form, for research into new cell functions. These discoveries concerning the structure of the cDNA and gene structure of GCAP-II can be used for future diagnostic and therapeutic concepts based on the invention.
机译：本发明涉及一种来自人血的肽，称为GCAP-II（鸟苷酸环化酶激活肽），其结构已被阐明，以将该物质用作诊断，医学和工业用途的药物。 GCAP-II肽的分离证明了它的存在。从GCAP-II中去除某些氨基酸会降低其生物学效力。人血中循环的GCAP-II与合成的GCAP-II参考物质相同，但与其他肽或其片段不同。已经使用质谱法发现了GCAP-II的分子式。与其他GCAP-II片段相比，GCAP-II的生物学活性不同，并且三维肽结构的差异也表明该GCAP-II片段是一种高质量的天然肽，属于具有适合用于治疗多种疾病，这些疾病与细胞中的电解质运输紊乱密切相关，还用于治疗特别是内分泌器官疾病。此外，GCAP-II可以工业上用作天然原料提取物，也可以纯化形式用于研究新的细胞功能。这些关于cDNA的结构和GCAP-II的基因结构的发现可用于基于本发明的未来诊断和治疗概念。

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