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Oncogene expression ntrk1 derivatives in pheochromocytoma PC12 cells and use thereof for screening anti-tyrosine kinase compounds.
Oncogene expression ntrk1 derivatives in pheochromocytoma PC12 cells and use thereof for screening anti-tyrosine kinase compounds.
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机译：嗜铬细胞瘤PC12细胞中癌基因表达ntrk1衍生物及其在筛选抗酪氨酸激酶化合物中的用途。
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摘要
The present invention provides a system cell culture IN VITRO BASED ON NEURAL CELLS COMPRISING DERIVATIVES oncogenic NRTK1 GENE RECEPTOR NGF (FACTOR OF NERVE GROWTH), and exhibiting neuronal differentiation INDEPENDENT NGF which has a great resemblance to the CELLULAR NGF-induced responses in normal cells, but differs OF THESE ANSWERS FOR PRESENTING CELL DEGENERATION AFTER PROLONGED PERIODS OF FARMING. The present invention further provides expression vectors Eukaryotic cDNAs encoding CONTAINING oncoprotein TRKT1 DERIVED NRTK1, and a method for obtaining such cells NEURAL by transformation with eukaryotic expression vectors encoding oncogenic NTRK1 DERIVATIVES.
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