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A cancer associated gene, testis-associated helicase (tah), protein expressed therefrom and uses thereof

机译：癌相关基因，睾丸相关解旋酶（tah），由其表达的蛋白质及其用途

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摘要

We have now discovered that eukaryotes, including mammals, have a gene that encodes a multifunctional protein having helicase activity, DNA repair activity, p53 sequestering activity and oncogenetic transformation potential. Enhanced transcripts and expression of this gene in non-testicular cells have a high correlation to disease state in a number of cancers, such as colorectal carcinomas, hereditary cancers resulting from defects in DNA repair pathways, breast cancers, etc. Accordingly, discovering enhanced levels of transcript or gene product in non-testicular tissues can be diagnostic of a predisposition to cancer, and prognostic for a particular cancer.

机译：现在我们已经发现，包括哺乳动物在内的真核生物都具有一个基因，该基因编码具有解旋酶活性，DNA修复活性，p53螯合活性和致癌基因转化潜能的多功能蛋白质。非睾丸细胞中该基因转录本的增强和表达与多种癌症的疾病状态高度相关，例如结肠直肠癌，DNA修复途径缺陷导致的遗传性癌症，乳腺癌等。因此，发现其水平升高非睾丸组织中的转录物或基因产物的表达可以诊断出癌症的易感性，并可以预测特定的癌症。

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公开/公告号AU4689696A

专利类型
公开/公告日1996-07-24

原文格式PDF
申请/专利权人 DANA-FARBER CANCER INSTITUTE;
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申请/专利号AU19960046896
发明设计人 LAN BO CHEN;SHIDENG BAO;
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申请日1995-12-28
分类号C12N15/52;C12N9/00;C12Q1/68;C07K14/47;C07K16/18;C12N15/11;A61K38/43;G01N33/68;C12N5/10;A01K67/027;
国家 AU
入库时间 2022-08-22 03:49:42

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