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MATERIALS AND METHODS RELATING TO THE DIAGNOSIS AND PROPHYLACTIC AND THERAPEUTIC TREATMENT OF SYNOVIAL SARCOMA

机译：与滑膜肉瘤的诊断，预防和治疗有关的材料和方法

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摘要

The invention provides a method for diagnosing the presence or absence of synovial sarcoma which comprises obtaining a sample derived from a tissue of a subject; contacting the sample with a specific binding member (sbm) which is specific for a binding partner (bp) which is characteristic of synovial sarcoma such that the presence of bp in the sample is diagnostic of synovial sarcoma, the bp being absent from an equivalent sample derived from a subject without synovial sarcoma; and detecting any binding of the sbm to its bp. Binding partners characteristic of synovial sarcoma are SSX and SYT sequences and fusion sequences thereof. Sequences, reagents and therapeutic methods and pharmaceuticals are also provided.

机译：本发明提供了一种诊断滑膜肉瘤的存在或不存在的方法，该方法包括获得来自受试者组织的样品。使样品与对滑膜肉瘤特征性的结合伴侣（bp）有特异性的特异性结合成员（sbm）接触，从而使样品中bp的存在可诊断为滑膜肉瘤，而等效样品中不存在bp来自没有滑膜肉瘤的受试者;并检测sbm与其bp的任何结合。滑膜肉瘤的特征性结合伴侣是SSX和SYT序列及其融合序列。还提供了序列，试剂和治疗方法以及药物。

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公开/公告号CA2195531A1

专利类型
公开/公告日1996-02-01

原文格式PDF
申请/专利权人 CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED;
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申请/专利号CA19952195531
发明设计人 COOPER COLIN STEPHEN;GUSTERSON BARRY AUSTIN;
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申请日1995-07-19
分类号C12N15/62;C07H21/00;A61K48/00;C07K19/00;C12N15/12;C07K16/18;A61K39/395;C07K14/47;G01N33/574;C12Q1/68;A61K31/70;C07K14/82;
国家 CA
入库时间 2022-08-22 03:50:22

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