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INTERFERON-GAMMA PRODUCTION INDUCING POLYPEPTIDE, MONOCLONAL ANTIBODY, AND AGENT FOR INTERFERON-GAMMA SUSCEPTIVE DISEASE

机译：干扰素-γ的产生诱导多肽，单克隆抗体和干扰素-γ疑难病治疗剂

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摘要

A polypeptide which has a molecular weight of 18,500 daltons on SDS-PAGE and a pI of 4.9 polypeptide strongly induces the IFN-.gamma. production by immunocompetent cells with only a small amount, and dose not cause serious side effects even when administered to human in a relatively-high dose. It is readily prepared by using a monoclonal antibody obtained from hybridomas, and incorporated into agents for treating and/or preventing malignant tumors, viral diseases, bacterial infectious diseases, and immune diseases.

机译：在SDS-PAGE上分子量为18,500道尔顿且pI为4.9多肽的多肽强烈诱导IFN-γ。免疫活性细胞仅产生少量的毒素，即使以相对高的剂量向人给药也不会引起严重的副作用。通过使用获自杂交瘤的单克隆抗体容易地制备，并将其掺入用于治疗和/或预防恶性肿瘤，病毒性疾病，细菌感染性疾病和免疫性疾病的药剂中。

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公开/公告号CA2162353A1

专利类型
公开/公告日1996-05-16

原文格式PDF
申请/专利权人 KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO;
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申请/专利号CA19952162353
发明设计人 USHIO SHIMPEI;TORIGOE KAKUJI;TANIMOTO TADAO;OKAMURA HARUKI;KUNIKATA TOSHIO;TANIGUCHI MUTSUKO;KOHNO KEIZO;FUKUDA SHIGEHARU;KURIMOTO MASASHI;
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申请日1995-11-07
分类号C12N15/12;A61K38/17;C07K16/18;C12N5/18;C12N1/21;C07K1/22;C07K14/435;G01N33/577;
国家 CA
入库时间 2022-08-22 03:50:32

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