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Novel protein inhibitors of serine proteinases (e.g. furin) derived from turkey ovomucoid third domain
Novel protein inhibitors of serine proteinases (e.g. furin) derived from turkey ovomucoid third domain
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机译：土耳其卵类粘液第三域衍生的新型丝氨酸蛋白酶蛋白抑制剂（例如弗林蛋白酶）
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摘要
Novel protein inhibitors of serine proteinases incorporating immediately adjacent to the inhibitor reactive site peptide bond a consensus sequence from substrates of a particular proteinase. The inhibitors include Kazal family inhibitors of subtilisin-like proteinases, and more particularly analogs of turkey ovomucoid third domain protein (6-56) such as A15R-T17K-L18R. The inhibitors inhibit the proteinase activity of enzymes such as human furin. There are further provided polynucleotides comprising one or more sequences of nucleotide bases collectively encoding the amino acid sequence of one of said turkey ovomucoid third domain peptide inhibitors; an expression vector comprising such a polynucleotide; an organism transformed with such an expression vector; and methods of synthesizing such an inhibitor and of inhibiting a serine proteinase.
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